2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131838A
    N6-4-aminobutyl-ADP trisodium
    N6-4-aminobutyl-ADP (6-AB-ADP) trisodium is an ADP derivative that can be used as a nucleotide mimetic or coupling agent for labeling enzyme substrates (such as kinases), constructing biological probes, or functionalizing nucleotide chains.
    N6-4-aminobutyl-ADP trisodium
  • HY-W1119956
    5’-(E)-VPG Phosphoramidite
    5'-(E)-VPG Phosphoramidite (5'(E)-VP-2'-OMe-iBu-GPhosphoramidite) is a structurally modified phosphoramidite reagent used to synthesize biologically stable oligonucleotides. 5'-(E)-VPG Phosphoramidite (POM) carries a VP protecting group and can be coupled to the target oligonucleotide at the 5' end via solid-phase synthesis. The modified oligonucleotide is then constructed through oxidation and deprotection steps. 5'-(E)-VPG Phosphoramidite is suitable for RNAi and viral replication research.
    5’-(E)-VPG Phosphoramidite
  • HY-145976
    m7GpppGpG
    m7GpppGpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppGpG prevents premature degradation by 5′-exonucleases and recruits proteins required for pre-mRNA splicing, mRNA transport and initiation of protein biosynthesis.
    m7GpppGpG
  • HY-171519
    2′-O-MOE-CMP
    2′-O-MOE-CMP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-O-MOE-CMP
  • HY-137692A
    2',3'-Dideoxyuridine-5'-O-(1-thiotriphosphate) tetrasodium
    2',3'-Dideoxyuridine-5'-O-(1-thiotriphosphate) (ddUTPαS) tetrasodium is a sulfur-containing nucleoside triphosphate derivative.
    2',3'-Dideoxyuridine-5'-O-(1-thiotriphosphate) tetrasodium
  • HY-N15369
    3′-GMP
    3′-GMP is a nucleotide that can be isolated from the tubers of Jerusalem artichoke (Helianthus tuberosus L.).
    3′-GMP
  • HY-177372
    saRNA negative control
    saRNA negative control is a saRNA and can be used as a negative control.
    saRNA negative control
  • HY-W1119946
    (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate
    (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate is a laurate derivative with a dimethoxytrityl (DMT) protecting group and a 3-pyrrolidinol structure. (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate can be used for oligonucleotide modification or as a lipid-soluble delivery vehicle.
    (3R,5S)-5-O-DMT-3-pyrrolidinol-benzyl laurate
  • HY-W881216
    (S)-GNA-T-phosphoramidite
    (S)-GNA-T-phosphoramidite (Compound 4) is a phosphoramidite compound that can be used for the synthesis of oligonucleotides.
    (S)-GNA-T-phosphoramidite
  • HY-103185R
    CCPA (Standard)
    CCPA (Standard) (2-Chloro-N6-cyclopentyladenosine (Standard)) is the analytical standard of CCPA (HY-103185). This product is intended for research and analytical applications. CCPA (2-Chloro-N6-cyclopentyladenosine) a highly selective A1 adenosine receptors agonist with a Ki of 0.4 nM. CCPA selectively binds to adenosine A1 over adenosine A2 receptors (Ki of 3900 nM). CCPA is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    CCPA (Standard)
  • HY-B0158S5
    Cytidine-13C9,15N3
    Cytidine-13C9,15N3 is the 13C and 15N labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-<sup>13</sup>C<sub>9</sub>,<sup>15</sup>N<sub>3</sub>
  • HY-131759A
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate sodium
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate (2'-NH2-ADP) sodium is an amine-modified nucleotide and a structural analog of the purine nucleotide ADP.
    2'-Amino-2'deoxyadenosine-5'-O-diphosphate sodium
  • HY-171530
    2'-O-MOE-GTP
    2'-O-MOE-GTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2'-O-MOE-GTP
  • HY-125650A
    Pseudouridimycin TFA
    Pseudouridimycin (PUM) TFA is an antibiotic that selectively inhibits bacterial RNA polymerase (RNAP), with an IC50 of about 0.1 μM and MICs of 4-6 μg/mL. Pseudouridimycin TFA is a C-nucleoside analogue that's effective against both Gram-negative and Gram-positive bacteria. Pseudouridimycin TFA inhibits bacterial growth in vitro and shows activity in a mouse model of purulent streptococcal peritonitis.
    Pseudouridimycin TFA
  • HY-103400R
    8-Chloroadenosine (Standard)
    8-Chloroadenosine (Standard) is the analytical standard of 8-Chloroadenosine. This product is intended for research and analytical applications. 8-Chloroadenosine (8-Cl-Ado), a unique ribonucleoside analog, depletes endogenous ATP that subsequently induces the phosphorylation and activation of AMPK. 8-Chloroadenosine induces autophagic cell death. 8-Chloroadenosine effectively inhibited in vivo tumor growth in mice.
    8-Chloroadenosine (Standard)
  • HY-171618
    Morpholino U subunit
    Morpholino U subunit is one of the basic units that make up morpholino oligonucleotides. Morpholino U subunit can pair with adenine in the target RNA.
    Morpholino U subunit
  • HY-13605AR
    Cytarabine hydrochloride (Standard)
    Cytarabine (hydrochloride) (Standard) is the analytical standard of Cytarabine (hydrochloride). This product is intended for research and analytical applications. Cytarabine hydrochloride, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.
    Cytarabine hydrochloride (Standard)
  • HY-157504
    2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA
    2’-O-Methyl-5’-O-phosphonoadenylyl-(3’→5’)-guanosine (TEA) is a trinucleotide cap analogue that regulates protein expression in living cells.
    2′-O-Methyl-5′-O-phosphonoadenylyl-(3′→5′)-guanosine TEA
  • HY-176025
    2'-Deoxy-3'-O-pivaloyladenosine-5'-O-triphosphate triethylammonium
    2'-Deoxy-3'-O-pivaloyladenosine-5'-O-triphosphate (3'-O-Pivaloyl dATP) triethylammonium is a derivative of 2'-Deoxyadenosine-5'-triphosphate trisodium (HY-136648A).
    2'-Deoxy-3'-O-pivaloyladenosine-5'-O-triphosphate triethylammonium
  • HY-177196
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-adenosine
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-adenosine is a nucleotide analogue used in nucleic acid synthesis.
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-adenosine